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Neonatal Formulary 9th Edition
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2, th,9 Edition February 2008, 3,Units,1 kilogram kg 1000 grams. 1 gram g 1000 milligrams,1 milligram mg 1000 micrograms. 1 microgram 1000 nanograms,1 nanogram 1000 picograms. A 1 weight by volume w v solution contains 1 gram of substance in 100 mL of solution A 10 . weight by volume w v solution contains 10 grams of substance in 100 mL of solution. It therefore follows that , 1 mL of a 1 solution 1 100 will contain 10 milligrams of substance. 1 mL of a 0 1 solution 1 1000 will contain 1 milligram of substance. 1 mL of a 0 01 solution 1 10000 will contain 100 micrograms of substance. Adverse drugs reactions , If any adverse reaction to a drug is observed consider notifying this to the Regional Monitoring.
scheme for Paediatric Adverse Reactions Full details of reactions that should be reported a. sample of the yellow card and full details of the monitoring scheme are available from pharmacy. th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008. 4, th,9 Edition February 2008, 5, CONTENTS, Page, Drug contents 6. Drugs alphabetical 8, Appendix, Preparation of glucose strengths 221. Prescription writing standards 223, Drugs for emergency treatment of Inborn Errors of Metabolism 225. Guardrails data set 227, th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008.
6, CONTENTS, Drugs in alphabetical order ,A Aciclovir D Dexamethasone. Adenosine Digoxin, Adrenaline Diphtheria tetanus accellular pertussis . Alprostadil Prostaglandin E1 inactivated poliomyeleitis and. Alteplase rtPA haemophilus type B conjugated vaccine. Aminophylline Dobutamine, Amphotericin Liposomal Domperidone. Amoxicillin Dopamine, Atracurium Dornase Alfa, Atropine Doxapram. AZT see Zidovudine, E Enoxaparin,B BCG vaccine SSI intradermal Erythromycin.
Benzylpenicillin sodium Erythropoietin,C Caffeine citrate F Fentanyl. Calcium chloride Flecainide, Calcium resonium Flucloxacillin. Carnitine Fluconazole, Cefotaxime Flucytosine, Ceftazidime Flumazenil. Chloral hydrate Folic acid, Chloramphenicol Furosemide Frusemide . Chlorothiazide, Chlorphenamine Chlorpheniramine , Clonazepam G Gaviscon.
Curosurf Gentamicin, Cyclopentolate eye drops Glucose gel Hypostop . Glucose infusion, H Heparin sodium, Hepatitis B immunoglobulin. Hepatitis B vaccine, Human albumin solution, Hyaluronidase. Hydralazine, Hydrocortisone sodium phosphate, th,9 Edition February 2008. 7,I Ibuprofen P Q Pancuronium bromide, Immunoglobulin Paracetamol.
Indometacin Indomethacin Paraldehyde, Insulin Human neutral Phenobarbital Phenobarbitone . Isoprenaline Phenylephrine eye drops, Phenytoin,J K Potassium acid phosphate. Potassium canrenoate,L Levothyroxine Potassium chloride. Lidocaine Lignocaine Propranolol, Liothyronine Prostaglandin E1 Alprostadil . Protamine sulphate, Pyridoxine,M Magnesium sulphate.
Meningococcal C vaccine, Meropenem R Ranitidine, Metronidazole Rifampicin. Miconazole, Midazolam, Morphine sulphate S Salbutamol. Morphine sulphate for NAS Sodium bicarbonate, Multivitamins Sodium chloride. Mupirocin Sodium ferredate Sodium ironedetate , Spironolactone. Sucralfate ointment,N Naloxone hydrochloride Sucrose 24 Sweet Ease .
Nitric oxide, Nystatin, T Tazocin, Teicoplanin,O Octreotide Tetracaine Amethocaine . Tolazoline, Trimethoprim, Trometamol Tham , UV Vancomycin. Varicella zoster immunoglobulin, Vitamin D Calciferol . Vitamin K1 Phytomenadione , WX, YZ Zidovudine, th. The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008. 8, Aciclovir, Prevents DNA synthesis of herpes viruses by inhibition of viral DNA.
polymerase enzyme Aciclovir is incorporated into viral DNA and. prevents viral replication, Indications for use Treatment and prophylaxis of herpes simplex types I and II and. varicella zoster infections,Preparation 25 mg in 1 mL solution in 10 mL. Add 1 mL of the solution to 4 mL of diluent to produce a final. concentration of 5 mg in 1 mL, After reconstitution use immediately and discard remainder. Administration, Dosage Prophylaxis, 15 mg kg 12 hourly 34 weeks. 8 hourly 34 weeks, Treatment of CNS and disseminated herpes simplex disease 1.
20 mg kg 8 hourly, Minimum course of 14 days, CNS and disseminated herpes simplex virus for 21 days 1. Renal impairment, 15 mg kg 12 hourly in mild renal impairment. 15 mg kg 24 hourly in moderate renal impairment, 7 5 mg kg 24 hourly in severe renal impairment. Routes Slow IV infusion over 1 hour, Oral administration is not recommended as only 10 to 20 of the dose. is absorbed, Compatibility Glucose 5 , Glucose 4 0 sodium chloride 0 18 .
Sodium chloride 0 9 , Incompatibility Amphotericin. Dobutamine, Dopamine, Metronidazole, Morphine sulphate. Parenteral nutrition, th,9 Edition February 2008, 9. Interactions, Storage Locked medicine cupboard Use once only then discard remainder. If refrigerated precipitation may occur This will re dissolve on warming. to room temperature without loss of potency,Side Effects Abnormal liver function tests.
Increase in urea and creatinine, Anaemia, Thrombocytopenia. Leucopenia, Renal impairment, Local reaction, Rash. Gastrointestinal disturbance, Convulsions, Agitation. Tremor, Angioedema, Anaphylaxis, Photosensitivity. Contra indications None known, Other Maintain adequate hydration to prevent deposition in the renal tubules.
The drug is most effective early in the infection as incorporation into. viral DNA is highly selective for infected cells during the phase of viral. replication, If varicella zoster infection is suspected then use of varicella zoster. Immunoglobulin should be discussed with senior staff at the Public. Health Laboratory Service, In CNS and disseminated herpes simplex virus disease decreasing the. aciclovir dosage or administering granulocyte colony stimulating. factor should be considered if the absolute neutrophil count remains. below 500 mm3 for a prolonged period1, 1 Kimberlin DW Lin C Y Jacobs RF et al Safety and efficacy of high dose intravenous acyclovir in the. management of neonatal herpes simplex virus infections Pediatrics 2001 108 230 238. th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008. 10, Adenosine, Anti arrhythmic agent, Stimulates adenosine receptors and slows conduction through the.
atrio ventricular node, Indications for use Paroxysmal supraventricular tachycardia. Preparation 3 mg in 1 mL solution supplied in 2 mL vials. Administration, Dosage 150 micrograms kg dose, Increase by 50 micrograms kg dose every 2 minutes to a maximum of. 300 micrograms kg dose, Routes IV very rapidly over 2 seconds flushed through with. sodium chloride 0 9 , Compatibility Sodium chloride 0 9 . Incompatibility Amphotericin, Interactions Theophylline can inhibit effect of adenosine.
Caffeine can inhibit effect of adenosine,Storage Locked medicine cupboard. th,9 Edition February 2008, 11,Side Effects Flushing. Dyspnoea, Bronchospasm, Sweating, Palpitations, Hyperventilation. Bradycardia, Heart block, Asystole, Continuous cardiac monitoring must be used and facilities for cardio . respiratory resuscitation must be available Continuous ECG tracing. should be performed whenever possible during administration of. adenosine, Contra indications 2nd or 3rd degree atrio ventricular block.
Sick sinus syndrome, Other A recent report has shown that the usually quoted starting does of 50. micrograms kg dose is effective in 10 of infants and children and. 100 micrograms kg dose is effective in 25 of infants and 50 of. children 150 micrograms kg dose is more effective in children 80 . than in infants 35 There thus seems little point in starting at a. dose of 50 micrograms kg dose as has been the case up until now. 1 Dixon J et al Guidelines and adenosine dosing in supraventricular tachycardia Arch Dis Child 2005 90 1190 1191. th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008. 12, Adrenaline, Stimulates alpha and beta adrenergic receptors. Increases the strength and rate of cardiac contractions and causes. peripheral vasoconstriction, Indications for use To increase blood pressure adrenaline will increase both systolic and. diastolic pressures , As a cardiac stimulant in asystole or profound intractable bradycardia.
Preparation 1 1 000 in 1 mL ampoules 1000 micrograms in 1 mL . 1 10 000 in 10 mL ampoules 100 micrograms in 1 mL . Administration, Dosage Hypotension , 0 2 micrograms kg minute increasing until response observed2. Add 1 2 mL of Adrenaline 1 1000 concentrated solution to 18 2 mL. of glucose 5 to produce a final concentration of 60 micrograms in. 1 mL, ADREnaline 60mcg ml, 1200 g 20 ml 60 g ml , Add 4 mL of Adrenaline 1 1000 concentrated solution to 16 mL of. glucose 5 to produce a final concentration of 200 micrograms in. 1 mL, ADREnaline 200mcg ml, 4000 g 20 ml 200 g ml . Resuscitation , 0 1 mL kg of 1 10 000, increasing to 0 3 mL kg of 1 10 000 IV or IO 1. Dose for intracardiac administration is the same as for IV. administration, Anaphylaxis, Preterm infants, 10 micrograms kg 0 01 mL kg of 1 1000 by deep IM 1.
Term to 6 months, 50 micrograms 0 05 mL of 1 1000 by deep IM 1. 6 months to 6 years, 120 micrograms 0 12 mL of 1 1000 by deep IM 1. Dose may be repeated after 5 minutes if no clinical improvement. th,9 Edition February 2008, 13, Routes IV infusion. IO, ET, Intracardiac injection, Compatibility Glucose 5 . Glucose 10 , Glucose 4 0 sodium chloride 0 18 , Sodium chloride 0 9 .
Glucose 10 stable for 1 hour , Incompatibility Alkalis. Amphotericin, Metronidazole, Sodium bicarbonate, Interactions Beta blockers pressor effects may be markedly increased. Doxapram risk of hypertension,Storage Locked refrigerator at 2 to 8 C. Side Effects Tachycardia, Hypoglycaemia, Arrhythmias. Bradycardia, Urinary retention, Hypotension, Cardiac arrest.
Hypertension,Contra indications None known, Other If there is no response at this dose a maximum of 1 0 mL kg of. 1 10 000 IV has been used However there is no evidence of any. benefit and some evidence to suggest higher doses may be. dangerous, Resuscitation Council guidelines 2005 state that administration of. adrenaline via an ET route is no longer considered appropriate. 1 Resuscitation at birth The newborn life support manual Resuscitation Council UK 2005. 2 Ng PC Lee CH Lamb CWK et al Transient adrenocortical insufficiency of prematurity and hypotension in very. low birthweight infants Arch Dis Child Fetal Neonatal Ed 2004 89 F119 F126. th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008. 14, Alprostadil Prostaglandin E1 , Vasodilator with specific action on the tissues of the ductus arteriosus. Inhibitor of platelet aggregation, Indications for use To maintain or restore patency of the ductus arteriosus.
Only to be used in infants who are ventilated or where. ventilation is immediately available,Preparation 500 micrograms in 1 mL. Low dose 20 nanograms kg minute, Add 0 1 mL of alprostadil 500 micrograms in 1 mL to 49 9 mL of. glucose 5 or sodium chloride 0 9 to produce a final concentration. of 1 microgram in 1 mL, ALprostad 1000ng ml, 50 g 50 ml 1 g ml . High dose 20 nanograms kg minute, Add 0 4 mL of alprostadil 500 micrograms in 1 mL to 49 6 mL of. glucose 5 or sodium chloride 0 9 to produce a final concentration. of 4 microgram in 1 mL, ALprostad 4000ng ml, 200 g 50 ml 4 g ml .
Do not store undiluted solution in plastic syringes Dilute immediately. after drawing up the solution as prostaglandin E1 can react with the. plastic causing formation of a haze If this occurs the solution and. syringes should be discarded immediately and replaced with fresh. solution,Administration, Dosage 10 nanograms kg minute. Initial dose should be increased until desired effect is obtained. Doses up to 400 nanograms kg minute have been reported. Routes Intravenous infusion, May be given orally but only on the recommendation of a paediatric. cardiologist, th,9 Edition February 2008, 15, Compatibility Glucose 5 . Sodium chloride 0 9 , Incompatibility Amphotericin. Metronidazole, Interactions,Storage Locked refrigerator at 2 to 8 C.
Side Effects Apnoea, Cardiac arrest, Hypotension, Convulsions. Tachycardia, Disseminated intravascular coagulation. Bradycardia, Diarrhoea, Hypothermia, Fever,Contra indications None. Other, th, The Jessop Wing Sheffield Teaching Hospitals NHS Trust 9 Edition February 2008.


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